Based on the urgent need of the southern region for qualified nurses, the Princess Aisha Bint Al Hussein College of Nursing was established at Al Hussein Bin Talal University in Ma'an in the academic year 2007/2008. The purpose behind that is to supply Ma'an Governorate, the south region, and Jordan in general with qualified nurses who are able to provide safe and efficient nursing care based on the latest scientific developments and research results. The college realized the need of the local community in the southern region to create new medical programs, so it took the initiative to open the medical analysis and radiography departments in the academic year 2013/2014 and the college collage name became The Princess Aisha Bint Al Hussein College of Nursing and Health Sciences. The Nursing Department at Princess Aisha College was able to attract a good number of distinguished faculty members who graduated from the most prestigious international and local universities, which contributed to the graduation of nurses known for their competence and distinction. The Nursing Department has also sent a number of distinguished graduates in order to obtain masters and doctorate degrees, which will have a great impact on the stability and permanence of the faculty members. The Nursing Department includes a group of specialized laboratories in the fields of nursing fundamental, health assessment, adult health, maternal health, child health, and critical care. The Nursing Department was keen to provide these laboratories with the latest equipment and models to train students. There is also a computer lab with internet access. In order to provide suitable and effective places for clinical training, the university signed agreements with the Ministry of Health and the Royal Medical Services to train students in their hospitals and health organizations. In view of the absence of a master's program in critical care in the southern region, the nursing department has created a master's program in acute care for adults. The teaching in this program began in the first semester of the academic year 2020/2021. Due to the good reputation that the nursing department has, the department has faced an increasing in the numbers of students who register in the bachelor’s and master’s programs.